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J&J Family of Companies Scientific Director, iPSC Cell Therapies in Spring House, Pennsylvania

Janssen Biologics (JBIO), Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Scientific Director, iPSC-derived Cell Therapy/CAR-T located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Exploratory Biology group of Janssen Biotherapeutics (JBIO) is seeking a highly motivated and independent researcher to lead the iPSC Cell Therapy team in Spring House, PA. You will be a key leader to advance Janssen’s efforts to deliver novel allogeneic cell therapy platforms to the clinic. Key activities will include but are not limited to: (1) directing and managing organizational strategy around iPSC-derived cell therapies, (2), providing scientific and technical guidance for external collaborations evaluating iPSC-derived cell therapies, and (3) partnering with the Oncology Therapeutic Area to lead preclinical programs through candidate selection.

The successful candidate will lead a multidisciplinary team dedicated to building an industry leading allogeneic cell therapy platform. You should have deep experience with state-of-the-art cell therapy approaches (diverse cell types, gene editing, synthetic biology), and be willing to apply your knowledge to overcome current limitations to unleash the full potential of cell therapies in oncology and beyond. Must be highly proficient in managing remote teams and alliances with academic and industry partners.

Primary responsibilities:

  • Serve as subject matter expert on iPSC biology and platform technology

  • Direct and lead teams of internal and external lab scientists to deliver iPSC-derived allogeneic cell therapies pursuant with organizational strategies

  • Support development and optimization of novel protocols for differentiation of iPSCs to immune lineage cells including T cells, NK cells, etc.

  • Validate and optimize methods for multiplexed gene editing and large transgene delivery in diverse cell types

  • Oversee development and testing of novel technologies to increase allogeneic cell therapy persistence, including but not limited to methods to overcome host-vs-graft reactivity against therapeutic cells

  • Create workplans for multiple external collaborations, and ensure timely execution on project deliverables

  • Partner with Therapeutic Area (TA) and cell therapy teams to support program-specific activities

  • Closely mentor junior scientists to further develop talent within the group

  • Foster a collaborative, creative, and rigorous culture of scientific discovery

Qualifications

  • Ph.D. in Biology or Immunology required

  • Minimum 10 years research experience in either CAR-T, iPSC biology, developmental biology, immunology, or cell and molecular biology required

  • Demonstrated experience leading small- to mid-sized scientific teams

  • Experience with CAR-T generation and functional characterization required

  • Experience with advanced cell therapy strategies (e.g. gene-edited, switchable CARs, multi-antigen CARs, non-viral gene delivery, etc.) strongly preferred

  • Experience with gene editing methodologies (CRISPR, TALEN, ZFNs) preferred

  • Experience with iPSC differentiation to immune subsets preferred

  • Familiarity with generation and interpretation of high-dimensional datasets (single cell RNA-seq, ATAC-seq, Cytof) preferred

  • Proven ability to manage multiple projects in a highly matrixed environment and lead cross-functional activities is required.

  • Must have excellent communication (both written and oral), time management, record keeping and data analysis and collaborative skills.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location

United States-Pennsylvania-Spring House-Welsh & McKean Roads

Organization

Janssen Research & Development, LLC (6084)

Job Function

R&D

Requisition ID

2005882681W

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